DISCOVERY CHEMISTRY SERVICES
Apeloa offers a full range of discovery support services, including a specialization in Medicinal Chemistry or Med-chem services. With Medicinal Chemistry centers of excellence in our three R&D facilities located in Boston (USA), Hengdian (China) and Shanghai (China), Apeloa has a proven ability to advance early-stage discovery and development of new molecules into manufacturable Starting Materials, Intermediates, and Active Pharmaceutical Ingredients (APIs).
FULL RANGE OF DISCOVERY CHEMISTRY SERVICES
Our Med-Chem service offering covers the entire spectrum of critical discovery services needed to develop optimized molecules quickly and efficiently for specific medicinal applications. Some of our key Med-chem services and activities include:
- Hit to lead
- Library screening
- Lead Generation
- Lead Optimization
- Building Block (BB) Library
- Intermediate collection
- Absorption, distribution, metabolism, and excretion(ADME)
- Pharmacophore Identification
THREE MODERN R&D SITES
Apleoa CDMO has established three modern R&D facilities designed to deliver world-class discovery support services. Apeloa CRO’s Boston (USA) R&D facility, launching in 2023, together with our Shanghai and Hengdian teams, will handle the full range of chemistry services from the earliest stages of med-chem modification to potential GMP scale-up of the molecule.
COMPOUND DESIGN AND SYNTHESIS SERVICES
Our goal is to efficiently develop highly bio-active molecules. Our Med-chem scientists can perform parallel/matrix library design and synthesis for hit identification and validation. Lead candidates are prioritized and optimized through analysis of key interactions, model pharmacophores, binding predictions and ADME/tox properties. Fully supported by analytical services, we utilize cutting edge tools like Mass-spectrometer-based services to detect and quantify the active ingredient and its metabolites/biomarkers to support pharmacokinetic studies.
Apeloa’s team has a wide range of state-of-the-art analytical instruments to provide a full spectrum of services. Please see our analytical page for more details on available instruments. We are building expanded SFC separation capability at our Shanghai R&D center and our ADME service is currently supported by our Hengdian China R&D center.
TECH-PACKAGE TRANSFER ADVANTAGE
When a customer begins the project with us at an early discovery stage, we will have key intermediates, marked impurity and technical know-how applied. This will greatly accelerate the tech-package transfer process to late development and manufacturing stages, which will save significant cost and time for the benefit of our customer. Apeloa is a leader in manufacturing in China and have the capability of offering a one-stop chemistry service, it’s beneficial for customers to being the project with our discovery chemistry service and then seamlessly tech transfer to scaled manufacturing.