Apeloa CDMO offers a wide range of core chemistries and technologies, with capabilities to develop and manufacture a wide range of molecules at the highest quality levels.  With over 20 years of experience with different synthesis routes and technologies, Apeloa CDMO has developed specialized capabilities allowing for the use of leading-edge technologies including Fluorination, Azidation, Asymmetry, Grignard reactions, Hydrogenation, Cyanidation, and Cryogenic reactions.    Our vast experience, modern facilities and reactors, complete in-house analytical support and attention to quality requirements, allows Apeloa CDMO to be a responsive partner for your contract regulated starting material (RSM), intermediate and API needs.


20 +

Years of chemistry experience

10000 m3

Total capacity

1800 +


3000 +

Metric tons of API annually

The manufacture of starting materials, intermediates, and Active Pharmaceutical Ingredients (APIs) can utilize a wide range of complex chemical and biological processes in order to efficiently produce the desired molecules. This requires a wide range of equipment such as chemical or biological reactors, analytical support, quality systems and technical know-how to produce materials suitable for the high standards required by today’s pharmaceutical industry.  Apeloa CDMO offers all of these elements to its contract customers around the world, reliably producing molecules in virtually at any scale using a wide range of core chemistry processes or technologies.


After more than 30 years of operations, Apeloa CDMO has been built to deliver the highest quality starting materials, intermediates and Active Pharmaceutical Ingredients (APIs) through our core chemistry operations. This means our customers can access the widest range of core chemistry processes and technologies, in the most modern facilities, provided by highly educated and experienced staff.  Apeloa CDMO has built an extensive chemical synthesis network of facilities with a large number of reactors designed to efficiently produce molecules by a variety of technology platforms. Our core chemistry capabilities begin in our R&D laboratories and finish with cost efficient and timely delivery of contracted products to our valued customers around the world. We are experts in core chemistry and pharmaceutical API manufacturing for global markets.

Large scale stainless steel reactors in GMP manufacturing facility for core chemistry operations at Apeloa CDMO.


Apleloa CDMO has developed a comprehensive offering of contract core chemistries that can produce the complex and high-quality starting materials, intermediates, and Active Pharmaceutical Ingredients (APIs) needed by today’s pharmaceutical industry. Our experience and capacity allow us to utilize everything from well-established synthesis steps to innovative leading-edge chemistries, which are fully supported and manufacturable in our state-of-the-art network of 13 global development and manufacturing facilities.  Some of the core chemistries offered by Apeloa CDMO include:

  • Fluorination (F2 & SF4)
  • Chlorination/Bromination (Cl2 & Br2)
  • Cyanidation (NaCN)
  • Azidation (NaN3)
  • Asymmetry reactions
  • Grignard Reactions
  • Hydrogenation
  • Cryogenic Reactions (-80oC)

Apeloa CDMO’s core chemistry capabilities cover everything from early-stage development and feasibility, product development & optimization (PD&O), scale-up to full scale cGMP commercial manufacturing.

Five blue large scale reactors in manufacturing suite at Apeloa CDMO for scalable synthetic chemistry.


Apeloa CDMO has built substantial chemical synthesis capacity across its network of facilities. With development services available in Boston (USA), Pudong Shanghai (China) and Hengdian Zhejiang (China) and five chemical API manufacturing sites in China, Apeloa CDMO has the capacity to supply your molecules at the required scale, fast and to the highest quality. Our cost-efficient manufacturing sites help us deliver competitive pricing along with responsive timelines and 1–2 weeks airfreight delivery of products.

Apeloa CDMO Capacity Statistics:

  • >10,000 mof total reactor capacity
  • >1,800 total reactors
  • 50 – 45,000 L reactor sizes
  • 3,000+ Metric tons/year API capacity
  • 25,000+ metric tons/year Intermediates capacity

Apeloa CDMO operates reactors constructed from a range of materials to support many reaction types and molecule requirements.  With reactors include those constructed with stainless steel, glass-lined, Hastelloy, titanium alloys, Monel, and Teflon contact materials, Apeloa CDMO has the chemical capacity to produce virtually any molecule at scale.

White mortar and pestle with pharmaceutical tablets and powder blend on a black background.


Being able to develop and manufacture such a wide range of molecules via so many core chemistries, means that having an in depth understanding of the chemistries must be combined with strong quality systems and a proven regulatory background. Our quality systems are regularly challenged through audits by major regulatory agencies, including the U.S. FDA, EDQM (EU) and the PMDA (Japan). These regulatory bodies have successfully inspected our facilities over 25 times, most recently in 2022. Our manufacturing sites hold GMP and ISO certifications and we are experienced in the preparation and submission of regulatory dossiers (ASMF, CEP, DMFs). Our contract services can include comprehensive CMC support including the provision of data in submission ready formats. Apeloa CDMO maintains these high levels of regulatory compliance so that customers can have confidence that the products we produce for them meet the highest quality standards. Our robust quality systems and staff training ensure that our employees are always putting the quality and compliance of customer products first.

Blue world map with air, sea and truck transport systems showing fast delivery by Apeloa CDMO.


Apeloa CDMO believes that its flexibility and responsiveness to customer needs is what makes us stand apart from the competition. Our ability to take in new contract projects, perform in-depth but rapid intake assessments, complete tech transfers and/or process development and bring the product safely to manufacturing is only possible because of our combination of people, capacity, experience, and customer service focus.  Our Chinese-based manufacturing sites understand the importance of not only manufacturing compliant high-quality products but also the importance of being delivering those products to our customers around the world on time.  Apeloa CDMO are international shipping experts, with 1-2 week logistics options by airfreight under flexible DDP, DDU & CIF (Incoterms) delivery terms.

Male analyst in a white h=lab coat standing in front of a red and black lab instrument performing and analytical test.


Our Core Chemistry contract services are fully supported by our R&D and analytical services groups.  Apeloa CDMO’s R&D groups in Boston (USA), Pudong Shanghai (China) and Hengdian Zhejiang (China) offer integrated development services that can take your molecule from an idea to manufacturing. With medicinal chemistry, synthetic chemistry and our PROTAC capabilities we can act as your research arm and determine an effective and robust synthesis route to produce your new molecule.  Apeloa CDMO also has grown its analytical services to be able to fully support these development requirements and develop/validate analytical methods that characterize the product as they move into manufacturing.  Apeloa has invested over US$10 million to build out its central laboratory facility with the most current analytical equipment, staffed by analytical scientists with a focus on drug testing. The central laboratory hosts specialized equipment and analysts that provide sophisticated analysis, characterization, and release of contracted customer products on a timely basis. With integrated development services and full in-house analytical support, Apeloa CDMO has the capabilities to deliver on your core chemistry needs for high-quality starting materials, intermediates, and Active Pharmaceutical Ingredients (APIs).