Synthetic chemistry capabilities are critical to developing robust and scalable chemical synthesis routes for today’s complex molecules. With high tech platform development and new modality chemistry options, Apeloa CDMO has the capabilities to advance your drug discovery project to become a reality. We design chemical synthesis routes that not only work on the bench but are fully scalable to production. Our experienced synthetic chemists support everything needed, from hit verification, making molecules for scaffolds, primary Structure-Activity Relationship (SAR) and patent coverage to resynthesis work, Apeloa CDMO’s synthetic chemistry teams are leaders in the industry.


Apleoa CDMO is staffed with experienced synthetic chemistry scientists and engineers, that provide integrated route synthesis services at virtually any stage of development. Many of our synthetic chemists hold an advanced degree (Ph.D. or M.Sc.) and bring decades of cumulative experience to our customer’s synthetic chemistry projects. Apeloa CDMO’s technical teams have the experience to plan your molecule’s entire synthetic route, with the scaled finished product in mind. We work closely with our Medicinal Chemistry teams to develop fully optimized molecules that perform the desired biological function and are realistically manufacturable.


Apeloa CDMO has the knowledge and capabilities to include a wide range of chemistry types in the design of customer synthesis routes. We have the knowledge and applied experience with a range of specialty technologies and chemistry types including:

  • Bone Slices
  • Corticosterone EIA
  • Dentine Discs
  • Bone Slices
  • Corticosterone EIA
  • Dentine Discs


Apeloa CDMO designs chemical synthesis routes appropriate for the stage of development.  We do however, plan for the future success of customer molecules by designing synthesis routes that are largely scalable and efficient enough to produce a commercially viable yield. At the earliest stages of development, a primary consideration is quickly producing enough purified material that allows the customer to conduct their pre-clinical activities and development.  Fast development in small quantities allows the customer to quickly generate product data and get to the next decision point that can impact funding of the project.

At all stages of development, the following critical parameters are assessed by Apeloa CDMO scientists towards a successful outcome.

  1. Yield – maximize the yield of the overall reaction, while achieving desired purity
  2. Cycle Time – design route to minimize overall cycle time to make the process efficient
  3. Number of chemical steps and convergence – reduce complexity of the process when possible and shorten manufacturing timelines
  4. Safety – manage chemistry steps that pose risk to safety or reaction stability
  5. Energy-consuming operations – Design synthesis route options that minimize the consumption of energy for the environment and cost efficiency


Apeloa CDMO designs chemical synthesis routes for many customers around the world. We take care to design synthetic routes for quality of output, but also consider the IP implications. Unique molecules can require unique chemistry to achieve. Any new chemistry synthesis steps that are fundamental to the customer molecule will belong to the customer so that their product is unencumbered. Apleoa CDMO also provides supporting data and documentation that supports the customer’s patent claims for custom contracted development.


Apeloa CDMO’s synthetic chemistry services are fully supported with our best-in-class analytical capabilities. With a full range of analytical capabilities, including Mass Spectrometry, HPLC/UHPLC and other highly powerful analytical instrumentation, we take pride in fully characterizing the process every step of the way. From impurity identification and resolution to the qualification of materials as reference standards we can perform your analytical testing needs in our modern laboratories and centralized analytical testing locations.


Apeloa CDMO is the Contract Development and Manufacturing Organization (CDMO) business of Apeloa. As a business unit dedicated to providing world-class contract services to the world’s leading biotechnology and pharmaceutical companies, our priorities always revolve around the customer. We believe that the foundation of our success as a service provider is rooted in our responsiveness, flexibility and quality of our services.

To build the contract development and manufacturing organization (CDMO) that pharmaceutical and biotechnology companies trust to discover, develop, and manufacture their most important products.

To make better pharmaceutical starting materials, intermediates, and APIs for our customers through superior technical skill, quality, and dedication to service. We are an innovative customer service organization built on science and technology.

Apeloa CDMO values are focused on providing science and service.


Apeloa CDMO is always learning. Whether that’s staying at the leading edge of our scientific knowledge or technological capabilities, advancing environmental health and safety systems to ensure a healthier and safer world, or developing new systems or ways of delivering services to our customer Apeloa CDMO is a learning organization.


We are dedicated to getting the job done for our customers. We act as an extension of our customer’s research, development, and manufacturing capacity. That means we focus on and deploy our world class capacity and people to meet our customer’s expectations. We offer exceptional and cost-efficient contract services that support long-term collaborative partnerships with our customers, stakeholders and employees.


Doing what it takes to deliver high-quality products and services on time and to budget is a core competency for Apeloa CDMO. We listen to our customers and find ways to always deliver by advancing technology, innovation, and dedication. Our goal is to always make our customers happy.